Chiral Intermediate ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE CAS 86728-85-0

Basic Info

Model No.:  86728-85-0

Additional Info

Packaging: 25KGS/DRUM

Productivity: 1T/M

Brand: VOLSENCHEM

Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: UNLIMITED

Certificate: ISO

Product Description

ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE CAS number is 86728-85-0, is a key chiral intermediate for the preparation of S-oxiracetam and statins. Statins are currently the best-selling cholesterol-lowering and lipid-lowering drugs in the world. Therefore, ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE as a key chiral intermediate in statins, has a large quantity demand and a wide range of applications. At present, there are two methods for producing ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE CAS 86728-85-0 as follows:
The first type: the use of epichlorohydrin by sodium cyanide ring-opening synthesis of 4-chloro-3-hydroxy butyl cyanide,then through ethanol and HCl acid alcoholysis reaction to give ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE, This method is very widely used today, but this method of production is cumbersome, and the yield is low.
The second type: the 4-chloro-3-hydroxybutyric acid ethyl ester is obtained by the catalytic hydrogenation of 4-chloroacetoacetic acid ethyl ester with hydrogen borohydride. Raceme Ethyl 4-chloro-3-hydroxybutyrate is splited to give the target compound. In this chemical resolution process, some precious chemical reagents are needed, the yield is also low, and the overall yield of the entire route is about 40%. Overall, the efficiency of this method is much lower than the first one.
In view of the above deficiencies and shortcomings, someone proposed a new idea: pure water plus ethyl acetate as a solvent, hydrogen phosphate as a solution pH buffer and ethyl 4-chloroacetoacetate as a reaction substrate, add above into vessel. The substrate is reacted so that the substrate undergoes an asymmetric reduction reaction in the presence of a biocatalyst and a hydrogen donor to form an S(-)-4-chloro-3-hydroxybutyrate ethyl ester solution, and sodium hydroxide buffer is added during the reaction. The pH of the whole reaction system was maintained at between 6.0 and 7.5. The reaction was followed by filtration, extraction and concentration under reduced pressure to obtain crude ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE.

Thera. Category: Organic Raw material 

Cas No.: 86728-85-0

Synonym: ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;(-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;Ethyl(S)-4-chloro-3-hydroxybutylate ;S-4-Chloro-3-hydroxybutyrate ;

Molecular Formula:C6H11ClO3

Molecular Weight: 166.6

Specifications: Available on request

Packing: Export worthy packing

Material Safety Data Sheet: Available on request