4-Fluoro-2-Methoxy-5-Nitroaniline For Mereletinib or AZD9291CAS 1075705-01-9

Basic Info

Model No.: 1075705-01-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Mereletinib (AZD9291) intermediate as known as 4-fluoro-2-Methoxy-5-nitroaniline CAS number 1075705-01-9, Molecular formula C7H7FN2O3, molecular weight 186.14. Related literature reported the process route as following, use 5 - fluoro - 2 - nitroanisole as raw materials, after reduction, nitrification, through two steps to get 4-fluoro-2-Methoxy-5-nitroaniline. However, the nitrification reaction in the second step is a violent exothermic reaction. If the temperature is too high, the product will be carbonized, so that it needs to be purified by column chromatography. Therefore, we believe that the literature recorded the feed control temperature below 10 ℃ is not correct. There is a way we think more reasonable,use 4-fluoro-2-methoxy nitrobenzene as raw material, through palladium-carbon catalytic reduction to get 4-fluoro-2-methoxy aniline, and then control its temperature below 0 ℃ , In part by adding concentrated sulfuric acid, until the system was dark brown, and then add potassium nitrate in batches, after adding finished, react for 10 hours. Then pour the reaction solution into ice water, stirred vigorously, slowly dropping ammonia water to pH between 7 and 8, when a yellow solid precipitated, filtered, washed with water and dried at 50 ° C under reduced pressure to give the target compound 4-fluoro-2-Methoxy-5-nitroaniline CAS number 1075705-01-9

Thera. Category: Anti-Neoplastic

Cas No.: 1075705-01-9

Synonym:4-Fluoro-5-nitro-o-anisidine;4-Fluoro-2-Methoxy-5-nitrobenzenaMine;Benzenamine, 4-fluoro-2-methoxy-5-nitro-;4-fluoro-2-methoxy-5-nitrophenylamine;4-fluoro-2-Methoxy-5-nitroaniline;2-Amino-5-fluoro-4-nitroanisole, 

Molecular Formula:C7H7FN2O3

Molecular Weight: 186.1404832

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

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AZD-9291 (1421373-65-0)
AZD-9291 (Mesylate)(1421373-66-1)
4-Fluoro-2-Methoxy-5-Nitroaniline( AZD9291 Intermediates) CAS 1075705-01-9

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4-FLUORO-2-METHOXYANILINE cas number 450-91-9