Organic Synthesis Reagents 4-Pyridinecarboxaldehyde CAS Number 872-85-5

Basic Info

Model No.: 872-85-5

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Port: Beijing,Shanghai,Shenzhen

Product Description

    4-Pyridinecarboxaldehyde CAS Number is 872-85-5. Appearance is a yellowish oily liquid, soluble in water and ether. 4-Pyridinecarboxaldehyde is an important product of organic synthesis reagents and an important starting material for the synthesis of donepezil hydrochloride. The synthesis method of 4-pyridinecarboxaldehyde includes the following: (1) Oxidation synthesis using 4-methylpyridine as a raw material, and this method has many by-products and low yield. (2) Oxidation synthesis using 4-pyridinemethanol as raw material. This method is the main method for synthesizing 4-Pyridinecarboxaldehyde CAS Number 872-85-5. Although the yield of the method is high, the price of 4-pyridine methanol is expensive, which makes the price of 4-Pyridinecarboxaldehyde higher. (3) Reduction of 4-pyridinecarboxaldehyde by 4-pyridine carbonitrile as a raw material, but this method also has the problem of high cost and high cost of raw materials. (4) 4-pyridine carboxamide is used as a raw material for selective oxidation to synthesize 4-pyridinecarboxaldehyde. The catalyst is relatively expensive and the yield is low. (5) Reduction with isonicotinic acid and its ester, the reducing agent is more expensive. One method is more feasible, the specific operation process is as follows:
    Step one, adding 26 g of isonicotinic acid to 23.76 g of o-phenylenediamine, heating to 160℃ for 4 h, then heating to 200℃ for 3 h, then heating to 260℃ for 3 h, cooling to room temperature, adding ethyl acetate Recrystallization to obtain 4-pyridine-2-benzimidazoline 33g, the yield was 84%;
Step two, 0.1 mol of 4-pyridine-2-benzimidazoline was dissolved in 40 ml of absolute ethanol, cooled to minus 10℃ under ice protection and ice bath, and 2 g of sodium borohydride was added in portions, and kept during the addition. The temperature does not exceed minus 5 degrees , and the reaction is carried out for 2 hours. After the reaction is completed, the unreacted sodium borohydride is quenched by the addition of ammonium chloride, the absolute ethanol is removed, and the oxalic acid solution having a pH of 2 is added thereto, and the mixture is heated under reflux for 2 hours. The mixture was adjusted to basic with sodium hydrogencarbonate and extracted with ethyl acetate to give 9 g of 4-Pyridinecarboxaldehyde in a yield of 85%.

Cas No.:872-85-5

Synonyms:Pyridine-4-aldehylde;AKOS BBS-00003164;4-PYRIDINECARBOXALDEHYDE;4-PYRIDINECARBALDEHYDE;4-FORMYLPYRIDINE;ISONICOTINALDEHYDE;ISONICOTINEALDEHYDE;LABOTEST-BB LT00942406
 

Molecular Formula: C6H5NO

Molecular Weight:107.11

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request