Hypoactive Sexual Desire Disorder (HSDD) Treatment of Flibanserin Hydrochloride 147359-76-0

Basic Info

Model No.: 147359-76-0

Additional Info

Packaging: As required

Productivity: 10KG/M

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

Flibanserin Hydrochloride CAS number is 147359-76-0, a new type of non-hormonal drug used to treat pre-menopausal women with acquired, generalized hypofunction and low libido. Early studies on the treatment of major depression with Flibanserin Hydrochloride found that although Flibanserin Hydrochloride had no antidepressant effect, it showed good efficacy in treating low libido, which prompted researchers to change their research direction and turn to research. It treats women with low sexual desire. Currently, treatment for low libido includes three therapies, such as psychotherapy, hormone therapy, and psychotropic medication. Psychopharmacological treatment is mainly to remove the pathogenic factors from the physiological level. Among the physiological factors, the current study is more clear that the central nervous system has abnormalities in the excitatory and inhibitory regulation of sexual response. In the central nervous system, the neurotransmitters that excite sexual responses are dopamine and norepinephrine, and the neurotransmitter that inhibits sexual response is 5-hyperoxytryptamine (5-HT). Flibanserin Hydrochloride is a cerebral cortical synaptic 5-HT1A agonist and a 5-HT2A antagonist with moderate affinity to dopamine D4, 5-HT2B and 5-HT2C receptors. On a physiological level, Flibanserin Hydrochloride binds 5-HT to its receptors on the postsynaptic membrane, making 5-HT unable to exert its inhibitory effect on sexual desire, thereby reducing the central inhibition of sexual response. The excitability is increased, so as to achieve the purpose of treating low sexual desire.
There are several main methods for the synthesis of Flibanserin Hydrochloride CAS number 147359-76-0:
1. Using 1-isopropenylbenzimidazolone as raw material, it can be obtained in five steps by various docking methods. The reaction step of the method is long, and in fact, the problem of a large number of reaction sites is not improved, and the drawback that the product is difficult to refine the high cost is not solved.
2. Using m-aminobenzotrifluoride as raw material and adopting the method of post-imidazole ketone, the Flibanserin Hydrochloride is obtained in four steps. The disadvantages of this route are also many. The highly toxic amine and nitro compounds are used as raw materials, and the reaction process is cumbersome. It is difficult to zoom in.
3. Using 1-isopropenyl-2-benzimidazolone as raw material, reacting with 2-bromoethanol under the catalysis of protic solvent and base, and obtaining Flibanserin Hydrochloride CAS 147359-76-0 in 4 steps. This method is easy to obtain raw materials, and the reaction process is simple and suitable for industrial production.

Thera. Category: Treatment of pre-menopausal women with hypoactive sexual desire disorder

Cas No.:147359-76-0

Synonyms:Flibanserin Hydrochloride;Flibanserin HCl

MF:C20H22ClF3N4O

NW:426.8630896

Assay: ≥98%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request