Alectinib intermediate 5 CAS 1256584-80-1

Basic Info

Model No.: 1256584-80-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Alectinib intermediate 5 has the chemical name of 9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile CAS number is 1256584-80-1, his synthesis process is as follows: 4.28g of ethyl 6-cyano-1H-indole-3-carboxylate and 50mL of THF solution were added to a 100mL three-necked flask. Then add 3.65g of 4-ethyl-3-hydroxybenzyl alcohol, cool down to -5 ~ 0℃, add a few drops of boron trifluoride diethyl ether solution, stir at -5 ~ 0℃ for 15min, continue to react to room temperature for 3 to 5 h, TLC was monitored until the end of the reaction. The obtained reaction system was washed with a saturated sodium hydrogen carbonate solution and washed with saturated sodium chloride, and the obtained organic phase was concentrated under reduced pressure to solids. The obtained crude product was slurried with a 1:2 cyclohexane/ethyl acetate mixture for 1.5 h to give an off-white solid 6-cyano-2-[2-[4-ethyl-3-hydroxyphenyl]methyl]- 1H-indole-3-carboxylic acid ethyl ester 5.85 gram.
    5.80 g of ethyl 6-cyano-2-[2-[4ethyl-3-hydroxyphenyl]methyl]-1H-indole-3-carboxylate and 20 mL of acetone solution were added into 100ml three-necked flask. 10 mL of a 1 mol/L sodium hydroxide solution and 10 mL of a 1 mol/L potassium dihydrogen phosphate solution were added dropwise, and solids were precipitated while stirring slowly. After suction filtration, the obtained solid was dissolved in a mixed solution of acetone/water = 1:1, and 10 mL of a 1 mol/L hydrochloric acid solution was added dropwise. The obtained reaction mixture was extracted with ethyl acetate and washed with saturated sodium hydrogen carbonate solution and washed with saturated sodium chloride, and then, the organic phase was concentrated under reduced pressure to solids, and solid was dissolved in 50 mL of N,N-dimethyl To the amide, 10 mL of 1,8-diazabicycloundec-7-ene was added, and the temperature was raised to 85 to 90 ° C. After stirring for 3 to 4 hours, 30 mL of water was added to precipitate a solid, and the solid was extracted with dichloromethane. The organic layer was concentrated under reduced pressure to give a solid, and the obtained solid was then lysed with a 1:1 methanol/water mixture to give 3.40 g of an off-white solid. It is Alectinib intermediate 5 CAS number 1256584-80-1.
Thera. Category: Anti cancer

Cas No.:1256584-80-1

Synonyms:  9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile;9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile-11

Molecular Formula:C21H17IN2O

Molecular Weight:440.27695

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request