Afatinib Quinazoline Nucleus CAS 162012-67-1

Basic Info

Model No.: 162012-67-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air,DHL

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Afatinib quinazoline nucleus CAS number 162012-67-1, Molecular formula C14H7ClF2N4O2, Melting point 242-244 ° C. It is the most important intermediate of Afatinib,Afatinib intermediate CAS162012-67-1 is the key on the entire manufacturing technology. Its structural design and the choice of ring-making timing are related to the fate of afatinib. As long as the Afatinib quinazoline nucleus can maintain a high yield, the total amount of waste water can be controlled, other links such as: functional group modification, side chain conversion are not too high difficulty. We  has been achieved production scale of  the aftatinib intermediate more than 100 kilograms in 2016, and specifically for domestic large pharmaceutical factory. Production of the normative and quality of the stability has been made highly recognized by customers.

Thera. Category:Anti- cancer

Cas No.: 162012-67-1

Synonym: (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;Afatinib intermediate A;7-Fluoro-6-Nitro-4(H)-Quinazoline4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-chloro-4-fiuoro-phen...;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide;

Molecular Formula: C14H7ClF2N4O2

Molecular Weight: 336.68

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3. CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

         4. 4-Bromocrotonic acid CAS  13991-36-1