848133-35-7,Trans 4-Dimethylaminocrotonic Acid Hydrochloride

Basic Info

Model No.: 848133-35-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air,DHL

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Trans 4-Dimethylaminocrotonic acid hydrochloride Cas number 848133-35-7 is for making Afatinib,Molecular formulais C6H12ClNO2. It belongs to a kind of amino crotonic acid derivatives,has a wide range of application in the synthesis of anti-tumor drugs.One of the most common is for the synthesis of Afatinib and Neratini.It reacts mainly with the corresponding intermediates by activation of the amide linker to get afatinib.It has a lot of preparation methods, but most of them existing environmental pollution defects. We can use diethyl malonate and 2,2-Diethoxy-N,N-dimethylethylamine as the starting material through three steps reaction to get the Afatinib side chain Cas number 848133-35-7, this method has obvious advantages, with low production costs, environmental pollution is small, Easy to operate. Our production of afatinib side chain is mainly provide supporting production services to the domestic large pharmaceutical factory with afatinib mother nucleus , our workshops and regulatory documents have passed a large pharmaceutical factory strict audit in several times from time to time.

Thera. Category:Anti- cancer

Cas No.:848133-35-7

Synonym:Afatinib intermediate E;(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;trans-4-Dimethylaminocrotonic acid hydrochloride;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE;(E)-4-(dimethylamino)but-2-enoic acid hydrochloride;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;

Molecular Formula: C6H12ClNO2

Molecular Weight: 165.62

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3. CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

        4. Trans 4-Dimethylaminocrotonic acid hydrochloride Cas number 848133-35-7