Afatinib Intermediate CAS Number 314771-88-5

Basic Info

Model No.: 314771-88-5

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air,DHL

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- is afatinib intermediate with the CAS number 314771-88-5, according to the literature, the original research company's synthesis,the final material can be obtained through fluorine atoms replacement, nitro reduction, amino amidation reaction. This method has many steps, the process is difficult to control, very few companies use this method. In contrast, we find that one method is more reliable, ade the compound 7-fluoro-6-nitro-4-hydroxyquinazoline, 3- (S) -hydroxytetrahydrofuran, alkali, organic solvent into reaction vessel,and take replaced reaction to get the first step of the compound and the second step of the compound is subjected to a suitable reduction process under the action of a reducing agent and then reacted with diethylphosphonic acid with a suitable condensing agent to form the corresponding compound, then react with Aldehyde to produce the third step compound, the third step compound and 3 - chloro - 4 - fluoroaniline, alkali, condensing agent and organic solvents to be reaction to get afatinib nitro cas 314771-88-5. This method is relatively easy to operate, the product looks very white.

Thera. Category:Anti- cancer

Cas No.: 162012-67-1

Synonym: (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine;Afatinib intermediate A;7-Fluoro-6-Nitro-4(H)-Quinazoline4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine;4-(3-chloro-4-fiuoro-phen...;4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline;N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide;

Molecular Formula: C18H14ClFN4O4

Molecular Weight:404.7795632

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3. CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

         4. 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- is afatinib intermediate with the    CAS number 314771-88-5, 

        5. (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine CAS 314771-76-1

        6.  3095-95-2,Diethylcarboxymethylphosphonate