2-[(5-bromo-2-fluorophenyl)Methyl]-Benzo[b]thiophene Used for Ipragliflozin CAS 1034305-17-3

Basic Info

Model No.: 1034305-17-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Ipragliflozin Intermediate named 2-[(5-bromo-2-fluorophenyl)Methyl]-Benzo[b]thiophene CAS number 1034305-17-3. In many literature reports, it is the starting material for the synthesis of Ipragliflozin. The most critical of the Ipragliflozin synthesis process is the coupling reaction of the Ipragliflozin benzylbenzothiophene and the hydroxy-protected glucono lactone derivative, which involves the formation of the halogen metal exchange reaction and the CC bond Reaction, many patent reports are related to the coupling CC bond synthesis method, but these methods use a relatively strong single n-butyl lithium reagent, it is necessary under the conditions of reaction less than -70 ℃ , due to the harsh conditions, it is not conducive to industrial production. It is well known that the energy consumption of ultra-low temperature operation in chemical reactions is considerable. In general, the reaction temperature of above -40 ℃ in the factory operate in conventional reactor can be more easily done, for less than -40 ℃ reaction is required to use special equipment or special reactor,it needs liquid nitrogen as a cooling source, the use cost is high. We believe that there is a synthetic method is very desirable that is use Ipragliflozin benzylbenzothiophene as raw materials, in the appropriate solvent of n-butyl ether, cyclopentyl methyl ether and toluene mixed with alkyl lithium reaction, later reacted with zinc Salt to make organic zinc reagent, then take substitution reaction with 2,3,4,6-tetravalent-pivaloyl-α-D-bromopyranoside nucleophilic to obtain the minus step of Ipragliflozin Intermediates CAS number 1034305-17-3, and then by the organic base to remove the pivaloyl protecting group to get te final API Ipragliflozin.

Thera. Category: Anti-Diabetes

Cas No.: 1034305-17-3

Synonym:Benzo[b]thiophene,2-[(5-broMo-2-fluorophenyl)Methyl]-;2-(5-BroMo-2-fluorobenzyl)benzothiophene;2-(5-BroMo-2-fluorobenzyl)benzo[b]thiophene; ;Ipragliflozin impurity B (B4);2-[(5-broMo-2-fluorophenyl)Methyl]-

Molecular Formula:C15H10BrFS

Molecular Weight: 321.2073032

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage:Ipragliflozin is a pharmaceutical drug for treatment of type 2 diabetes. Ipragliflozin, jointly developed by Astellas Pharma and Kotobuki Pharmaceutical,