Preparation of Epoxides Trimethylsulfoxonium Iodide CAS 1774-47-6

Basic Info

Model No.: 1774-47-6

Function: Nervous System Drugs

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Port: Beijing,Shanghai,Shenzhen

Product Description

Trimethylsulfoxonium iodide CAS number is 1774-47-6, molecular formula is C3H9IOS, molecular weight is 220.07. It can be treated with a strong base to form an ylide, which reacts with the ketone and carbonyl of the aldehyde to form an epoxide; it can also react with the double bond of the α,β-unsaturated ester to form a cyclopropane. ester. Trimethylsulfoxonium iodide is also an intermediate for the synthesis of tasamine, fluconazole, abiftam and other drugs. In addition, Trimethylsulfoxonium iodide CAS number 1774-47-6 is also an important raw material for making wood preservatives. The steps for preparing wood preservatives by trimethyl iodide sulfoxide are as follows: 1. Take trimethyl iodide sulfoxide at a mass ratio of 10:1, add sodium hydride, pass nitrogen protection, and add 5 times the mass of sodium hydride. The sulfoxide is stirred and mixed, and the mixture is stirred. The dried product is added to tetrahydrofuran at a mass ratio of 1:8 to obtain a mixed solution. The mixed solution is added to the stirred mixture at a mass ratio of 2:3, stirred at 50-55℃, filtered, and the filtrate is taken. Rotary evaporation to obtain a rotary evaporation;
2. Take aluminum chloride at a mass ratio of 8:6 to add m-dichlorobenzene, stir and mix at 0~4℃, then add 60% of n-pentanoyl chloride of the mass of aluminum chloride, stir the mixture at 65~70℃, heat up 80 The temperature is kept at ~90℃, cooled to room temperature, and the cooled product is obtained. The cooled product is added with hydrochloric acid at a mass ratio of 2:10, and allowed to stand at -2 to 1℃, and the precipitate is taken, distilled under reduced pressure, and dried to obtain a dried product;
3. Take 1,2,4-triazole sodium, add potassium carbonate and dimethylformamide at a mass ratio of 3:8:10, and mix and stir to obtain a mixture a, and obtain the rotary evaporated material obtained in step 1 at a mass ratio of 3:8. Adding to the stirring mixture a, stirring and mixing, cooling to room temperature, obtaining the cooling product a, adding distilled water at a mass ratio of 1:8, adjusting the pH to 6.5-7, extracting with ethyl acetate, and extracting the extract liquid under reduced pressure to obtain antiseptic Active agent.

Cas No.:1774-47-6

Synonyms: 
Trimethyloxosulphonium iodide;
Sulfoxonium,trimethyl-,iodide;
EINECS 217-204-2;
Trimethyl sulphoxonium ioidie;
dimethyloxosulfonium methylide;

Molecular Formula: C3H9IOS

Molecular Weight: 220.07

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request