Pamoic acid / EMBIONIC ACID CAS 130-85-8

Basic Info

Model No.: 130-85-8

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Pamoic acid also called EMBIONIC ACID CAS number 130-85-8. Competitive ELISA results show that the concentration of pamoic acid at 1 mg / ml can inhibit 2.71 ± 2.51% BLYS binding to TACI-Fc and inhibit 12.36 ± 6.38% at 3 mg / ml BLYS and TACI-Fc binding, at 5mg / ml it can inhibit 79.68 ± 2.68% BLYS and TACI-Fc binding, the results show that the role of inhibition has positive relation with concentration of pamoic acid.Non-binding BAFF small molecule compound benzoic acid that is negative reference, has no obvious inhibitory on the interaction between BLYS and TACI and no dose-dependent relationship. It is shown that the inhibitory effect of pamoic acid CAS number 130-85-8 is specific and effective. Researchers use computer molecular docking methods,combine
Chimera software explores the mechanism of action of pamoic acid and BLYS molecules. It was found that a benzene ring of Pamoic acid was inserted into the conserved hydrophobic pouch of BLYS to form a hydrophobic interaction with His69, Leu70, Ile92 and forms a π-cation effect with the side chains of Arg124 and Arg90 residues, BLYS, the two carboxyl groups interact with the key residues Arg124 and Arg90 of BLYS to form a stable salt bridge, and the other benzyl carbonyl groups interact with Arg124 to form hydrogen bonds.

Thera. Category: Inhibitor

Cas No.: 130-85-8

Synonym:EMBIONIC ACID;PamoicAcid98%;PAMOIC ACID pure;Pamoic Acid (250 mg);PAMOIC ACID FREE ACID;Pamoic;PaMoic aci;PAMOIC ACID;PalMer acid;EMBONIC ACID;

Molecular Formula:C23H16O6

Molecular Weight: 388.37

Purity: ≥98.%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request