Nintedanib Intermediate 3 CAS Number 1160293-25-3

Basic Info

Model No.: 1160293-25-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Nintedanib intermediate 3 CAS number is 1160293-25-3, with chemical name of 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, his synthetic route is as follows: 1. 4-chloro-3-nitrobenzoic acid was suspended in methanol, after adding thionyl chloride ,take  heating and refluxing reaction, and then cooled , Centrifuged and dried to give the first step methyl 4-chloro-3-nitrobenzoate. 2. Sodium tert-pentoxide was added to the Dimethyl malonate, which was then added to a hot solution of N-methyl-2- Pyrrolidone ; and then stirred and cooled, the mixture was acidified with dilute hydrochloric acid to pH = 1, filtered to obtain a solid, the solid was dissolved in acetic acid, added palladium on carbon catalyst catalytic hydrogenation at 45 ℃;after hydrogenation stopped , Heating the reaction material, filtering off the catalyst after heating, adding water at about 50 ° C, cooling the product to 5 ° C, centrifuging and drying at 50 ° C to obtain the second product, 2-oxindole -6-carboxylate. The second step was suspended in toluene at ambient temperature. Chloroacetic anhydride was added and the mixture was refluxed at 120 ° C for 3 hours, then cooled to 80 ° C and methylcyclohexane was added with 30 min and slowly cooled to ambient temperature, The mother liquor was separated and the solid was washed with ice-cold methanol and dried to give white crystals, which were the target compound Nintedanib intermediate 3, 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester CAS number 1160293-25-3.

Thera. Category:  Anti-cancer

Cas No.:  1160293-25-3

Synonym:Methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-2-oxo-, methyl ester;methyl 1-(chloroacetyl)-2-oxoindolin-6-ylcarboxylate;1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;

Molecular Weight: 309.32

Molecular formula:C18H15NO4

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request