Eliglustat or Genz 99067, CAS Number 491833-29-5

Basic Info

Model No.: 491833-29-5

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Eliglustat referred to as Genz 99067, CAS Number 491833-29-5, is a glucosyl-sphingosine synthase inhibitor, used as a specific I-type Geshe disease is the only first-line oral mediation. Goshen disease (GD) that is glucose mellitus disease, is a family of glycolipid metabolic diseases, chromosomal recessive inheritance, is the most common one in lysosomal deposition disease . Glucose mellitus is a soluble glycolipid material, is one of the components of the cell, widely found in the human body. Due to the lack of glucose cerebroside lipase caused glucose moss glycosides accumulate in the liver, spleen, bone and central nervous system mononuclear - macrophages and cause lesions. The listing of Eliglustat CAS 491833-29-5 has greatly changed the treatment of type I goshen disease.
The Preparation of Eliglustat is as following:1 - halogen 2 - nitroethane and pyrrolidine are reacting under the catalyst and the deacid reagent, Take the substitution reaction to produce 2- (pyrrolidin - 1 - yl) -1 - nitroethane, and then By its reaction with 2,3-dihydro-1,4-benzodioxan-6-aldehyde under the action of a chiral catalyst, then the product through nitro reduction and amidation reaction to get Eliglustat 491833-29-5. This kind of preparation method has been tested in many times, which is an ideal method.

Thera. Category: Inhibitors

Cas No.: 491833-29-5

Synonym:Eliglustat(Genz-99067);Eliglustat;Genz 99067;N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide;N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1- pyrrolidinyl)-2-propanyl]octanamide;

Molecular Formula:C23H36N2O4

Molecular Weight: 404.54294                    

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Synthesis Pharmaceutical Intermediates