Central Antihypertensive Drug Moxonidine Hydrochloride CAS 75438-58-3

Basic Info

Model No.: 75438-58-3

Additional Info

Packaging: 25KGS/DRUM

Productivity: 40T/Y

Brand: VOLSENCHEM

Transportation: Ocean,Land,Air

Place of Origin: CHINA

Product Description

Moxonidine hydrochloride has the cas number of 75438-58-3,which is the second generation of central antihypertensive drug. Its antihypertensive effect has been confirmed. It also shows a good hemodynamic effect. Due to its high selectivity to imidazoline I1 receptors and its weak effect on α2 receptors, moxonidine has a milder antihypertensive effect, with very mild side effects; fewer adverse reactions, no lethargy, no bradycardia, and no Drug rebound phenomenon. Compared with the first-generation central antihypertensive drug clonidine, its tolerability is higher, and moxonidine has a smaller effect on the heart rate of spontaneously hypertensive rats (SHR) and has a shorter duration.
Due to the small amount of moxonidine hydrochloride used in the treatment of high blood pressure, the tablet of moxonidine HCL has a small specification of only 0.2 mg. Conventional preparation of tablets can easily lead to large content uniformity and uneven drug mixing. Therefore, how to mix the smaller Moxonidine hydrochloride cas number 75438-58-3 in the preparation is a technical problem that researchers urgently need to solve. Some people use the freeze-drying method to disperse the main drug evenly in a certain carrier, and then use the powder direct tableting method to solve the problem of low content uniformity when the low-load drug formulation is directly compressed, but it becomes loose after freeze-drying. , Poor mobility, easy to absorb moisture, apparently not suitable for domestic production requirements for tablets. It has been reported in the literature that the drug is dissolved in a solvent such as ethanol. Although the degree of mixing may be increased to some extent, during the drying process, the drug gradually migrates as the solvent such as ethanol volatilizes, resulting in a large difference in drug content among the particles. In addition, the means of pulverizing the gas stream can increase the surface area of the drug, but at the same time, it also increases the viscosity of the drug, making it more difficult to mix the drugs.

Thera. Category: Anti-Hypertension  

Cas No.:75438-58-3

Synonym: BDF-5895 HCL;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-3H-pyrimidin-2-amine hydrochloride;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MOXONIDINE HCL;

Molecular Structure:  

Molecular Formula:C9H13Cl2N5O

Molecular Weight:278.14

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request