Cas 444731-72-0,2,3-Dimethyl-2H-indazol-6-amine For making Pazopanib Hydrochloride

Basic Info

Model No.: 444731-72-0

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale

Brand: VOLSENCHEM

Place of Origin: CHINA

Product Description

Pazopanib hydrochloride Intermediate  2,3-Dimethyl-2H-indazol-6-amine called Pazopanib aminoindazole CAS number is 444731-72-0. It is the key raw material of pazopanib, the strength of his synthetic technology determines the competitiveness of downstream products strength. There is a synthetic method is very worth learning, the specific steps are as following:1. Bromination reaction. Temperature control between 20-30 ° C, adding about 375 kg of 1,2-dichloroethane and 30 kg of o-nitroethylbenzene into1000L enamel kettle, the system heated to reflux, and with the temperature drop 36.5kg bromine to the system. After 5 hours of reaction, the reaction system was transferred to saturated aqueous sodium bisulfite solution, concentrated and then recrystallized from petroleum ether to give 4-bromo-1-ethyl-2-nitrobenzene. 2. Nitro reduction. 500 L reactors was added 105 kg of glacial acetic acid and 10 kg of 4-bromo-1-ethyl-2-nitrobenzene, and iron powder was added in portions to give 5-bromo-2-ethylaniline. 3. Diazo ring. 420 kg of glacial acetic acid and 20 kg of 5-bromo-2-ethylaniline were added into 1000l enamel kettle, and the aqueous solution containing 7.2 kg of sodium nitrite was rapidly added dropwise at a temperature of 5-15 ° C to give 6-bromo-3-methyl -2H-indole. 4. Methylation reaction.  added 284 kg of N, N-dimethylformamide and 30 kg of 6-bromo-3-methyl-2H-indole into 1000L enamel kettle, and 19.7 kg of dimethyl sulfate was added dropwise to give 6-bromo-2,3 -dimethyl-2H-indole. 5. Amination reaction. 200 L reactor was added 79 kg of ethanol, 10 kg of 6-bromo-2,3-dimethyl-2H-indole and 0.17 kg of cuprous iodide, through the reaction to obtain the target product of Pazopanib aminoindazole CAS number is 444731-72-0.
Currently on the market manufacturers have very mature process of pazopanib aminoindazole, the price is very low. Manufacturers of pazopanib can consider to buy this intermediate directly.

Cas No.: 444731-72-0

Synonym:6-Amino-2,3-dimethyl-2H-i...;2,3-DIMETHYL-2H-INDAZOL-6-AMINE;6-Amino-2,3-dimethyl-2H-indazole;2,3-Dimethyl-6-amino-2H-indazole;2H-Indazol-6-aMine, 2,3-diMethyl-;2,3-dimethyl-2H-indazol-6-ylamine

Molecular Formula:C9H11N3

Molecular Weight:161.2

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Pazopanib Intermediate lists:

2,3-Dimethyl-2H-indazol-6-amine, CAS  444731-72-0

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE,CAS 444731-73-1   

3-methyl-6-nitro-2H-indazole CAS number  1313372-75-6

2-Ethyl-5-nitrobenzenamine, CAS numbe  20191-74-6.

2-Methyl-5-AMiobenzenesulfonmide CAS 6973-09-7,

2-methyl-5-nitrobenzenesulfonamide  CAS number 6269-91-6,