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Blood Thinners Dabigatran Etexilate Mesylate Intermediate 212322-56-0

Payment Type:	L/C,T/T
Incoterm:	FOB
Min. Order:	1 Kilogram
Delivery Time:	15 Days

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Basic Info

Model No.: 212322-56-0

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

The N-3 intermediate of dabigatran etexilate, CAS number is 212322-56-0, abbreviated as dabigatran etexilate N-3. His preparation process is as follows: 38.9g of ethyl 3- (pyridin-2-ylamino) propionate and 37.3g of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide were dissolved in 500mL of dimethyl chloride, 39.2 g of 4-methylamino-3-nitrobenzoic acid and 38.8 g of N, N-diisopropylethylamine were added in lots at room temperature for 18 hours and monitored by TLC. After the reaction was completed, the solvent was removed under reduced pressure and dissolved with appropriate amount of ethyl acetate, washed with saturated sodium bicarbonate, saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was dissolved in ethyl acetate, the dried hydrogen chloride was passed through the solution until the solution was completely precipitated and filtered and dried , get the target crude compound dabigatran etexilate N-3 intermediate CAS 212322-56-0,. Then 1: 1 mixture of ethanol - acetonitrile was heated to dissolve, slowly cooled to 10 ° C, keep crystal for 2 hours, filtered and dried to get refined dabigatran etexilate N-3 intermediate 78.7g. The calculated yield was 95.2%. Product purity by HPLC was 99%.

Thera. Category: Antithrombotic/Blood thinners

Cas No.:212322-56-0

Synonym :Ethyl 3-{1-[3-aMino-4-(MethylaMino)-phenyl]-N-(pyridin-2-yl)-forMaMido}-propanoate;ethyl (2S)-2-{1-[3-aMino-4-(MethylaMino)phenyl]-N-(pyridin-2-yl)forMaMido}propanoate;3-[3-aMino-4-(MethylaMinobenzoyl)-pyridin-2-ylaMni] propionic acid ethyl ester;Ethyl N-[3-aMino-4-(MethylaMino)benzoyl]-N-pyridin-2-yl-beta-alaninate;3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER;N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-Alanine,ethylester;Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate;Dabigatran Intermediate 1;

212322-56-0

Molecular Weight: 342.39228

Molecular formula: C18H22N4O3

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: It can treat and prevent blood clots, reducing the risk of stroke.

Related intermediate:

CAS	Chemical Name	Specification		Color
41263-74-5	4-(MethylaMino)-3-nitrobenzoic acid	HPLC	≥99.0%	pale brown
103041-38-9	N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER	HPLC	≥99.0%	off white to white
429659-01-8	ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE	HPLC	≥99.0%	orange yellow solid
42288-26-6	N-(4-CYANO-PHENYL)-GLYCINE	HPLC	≥99.0%	off white
42288-26-6	N-(4-CYANO-PHENYL)-GLYCINE	Loss on drying	≤1.0%	off white
212322-56-0	3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER	HPLC	≥99.0%	off white
		Melting point	101.0°C~106.0°C
		Single impurity	≤0.3%
		Loss on drying	≤0.5%
		Residue on ignition	≤0.5%
		Assay	≥98.0%
211915-84-3	Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester	HPLC	≥99.0%	off white
		Single impurity	≤0.3%
		Loss on drying	≤0.5%
		Residue on ignition	≤0.5%
		Assay	≥99.0%
872728-85-3	N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate	HPLC	≥97.0%	off white
211915-06-9	Dabigatran Etexilate	HPLC	≥98.0%	white
		Single impurity	≤0.2%
		Loss on drying	≤1.0%
		Assay	≥98.0%
872728-81-9	Dabigatran etexilate mesylate	HPLC	≥99.0%	light yellow solid
		Single impurity	≤0.5%
		Loss on drying	≤1.0%
		Residue on ignition	≤0.1%
		Heavy melta	≤20 ppm
		Assay	≥98.5%

212322 56 0 CAS 212322 56 0 Dabigatran Etexilate N 3 CAS Number 212322 56 0

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