Azilsartan N-1 CAS Number 1403474-70-3

Basic Info

Model No.: 1403474-70-3

Additional Info

Packaging: 25KGS/DRUM

Productivity: 40T/Y

Brand: VOLSENCHEM

Transportation: Ocean,Land,Air

Place of Origin: CHINA

Product Description

There are three main synthetic methods about azilsartan N-1 cas number 1403474-70-3, the first one,use a relatively simple organic molecular material 3-nitrophthalic acid as the starting material, after esterification, acylation, azide, rearrangement, alkylation, deprotection , Reduction of nitro, cyclization imidazole ring, then reduction of cyano and other multistage reaction to obtain the target compound. This is the most common route, but this route has many steps and a longer production cycle. It uses relatively hazardous industrial chemicals such as thionyl chloride and sodium azide, and also uses high-pressure hydrogenation and reduction to produce Operation is more dangerous, safety is not high, is not conducive to large-scale industrial production. Due to the long route, more types of raw materials are used, the operation is complicated, the equipment is invested a lot, the yield is lower and the cost is higher.
The second one starts with methyl 1 - [(2'-cyanobiphenyl-4-yl) methyl] -2-ethoxy-1H-benzimidazole-7-carboxylate (abbreviated as A), The material is reduced with cyano and then esterified with N, N-carbonyldiimidazole. This procedure, while subtracting the previous step of intermediate A, when on the cyano reaction, due to the reaction temperature is relatively high, results in a higher 2-ethoxy easy to break the key, fall off the ethyl, the impurity increases. In the reaction process requires a lot of N, N-carbonyldiimidazole,The high price of N, N-carbonyldiimidazole is not conducive to industrial production.
The Third one: Ethoxybenzimidazole-7-carboxylic acid methyl ester and 2-aldehyde-4'-bromomethyl biphenyl are dissolved in a suitable solvent, adding a suitable base as a catalyst, at a suitable temperature, (2'-formylbiphenyl-4-yl) methyl] -2-ethoxybenzimidazole-7-carboxylate (IV) can be obtained by appropriate process. The appropriate amount of the base catalyst and an appropriate amount of oximation agent is dissolved in a suitable solvent, thoroughly mixed, and then add compound (IV), react at a suitable temperature,after the reaction is completed, through the appropriate treatment to give 1- [ (2'-carbalkoximebiphenyl-4-yl) methyl] -2-ethoxybenzimidazole-7-carboxylate (V). The compound (V) is dissolved in a suitable solvent, and an appropriate amount of a chlorinating reagent is added thereto at a suitable temperature and reacted at a suitable temperature to obtain 1 - [(2'-chloro (carboxydimino) - yl) methyl] -2-ethoxybenzimidazole-7-carboxylate (VI). The compound (VI) and the cyanate reagent are dissolved in a suitable solvent, and the ring is cyclized at a suitable temperature to obtain the target compound cas number 1403474-70-3 through proper treatment.

Thera. Category: Anti-Hypertension  

Cas No.:1403474-70-3

Synonym:ethyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate;Ethyl 2-ethoxy-1-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate;ethyl ester of azilsartan;1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, ethyl ester;1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid ethyl ester;

Molecular Structure:  

Molecular Formula:C27H24N4O5

Molecular Weight: 484.50326

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request