6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Used for Palbociclib 1016636-76-2

Basic Info

Model No.:  1016636-76-2

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Palbociclib main ring cas number 1016636-76-2, there are variety of synthesis ways, we mainly introduce two kinds of methods: The first, use 2-methylthio-4-chloropyrimidine-5-carboxylate and Cyclopentylamine as raw material, the target product Palbociclib main ring was obtained after 6 steps, this step is too long, and the reaction process using lithium aluminum hydride, in the production exists rish factor. And the entire route has low yield. Second, this method can be obtained after three steps of reaction, roughly as follows: 1) The coupling reaction of 2,6-dichloropyrimidine and cyclopentylamine in the presence of a base and an organic solvent gives the first Step product. During this step, the base is preferably triethylamine, diisopropylethylamine, triethylenediamine. Preferred organic solvents are dimethylformamide, dimethylacetamide, dimethylsulfoxide and ethyl acetate. 2) The Friedel-Crafts reaction of the first step with an acylating reagent under the action of a Lewis acid in the presence of a solvent gives the second step. The acylation reagent in the Friedel-Crafts reaction is preferably acetic anhydride, acetyl chloride, acetamide or acetonitrile; the Lewis acid is selected from aluminum trichloride, boron trichloride and the like; the solvent is selected from the group consisting of benzene, toluene, dichloromethane, tetrahydrofuran ; 3) reacting the riethyl phosphonobromoacetate with a base in the presence of a solvent to react with the second step product to complete the Wittig-Horner and ring-closure reaction in a one-pot process to obtain the target product Palbociclib main ring cas number 1016636-76-2.

Thera. Category:  Vasopressin Receptor

Cas No.: 1016636-76-2

Synonym: 6-broMo-2-chloro-8-cyclopentyl-5-;6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one;6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(For Palbociclib);6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one;PALBOCI

Molecular Weight: 342.61882

Molecular formula: C13H13BrClN3O

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request