5-Nitro-2-Methylbenzenesulfonamide CAS 6269-91-6

Basic Info

Model No.: 6269-91-6

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale

Brand: VOLSENCHEM

Place of Origin: CHINA

Product Description

2-methyl-5-nitrobenzenesulfonamide is an intermediate used for making pazopanib CAS number 6269-91-6, It can not be directly used for the synthesis of pazopanib, first it should be reduced to the form of amino compounds and then condensation and salify with pazopanib intermediate 7 to get the pharmaceutical raw material pazopanib hydrochloride. 2-methyl-5-nitrobenzenesulfonamide is developed by ourselves, not outsourced. The preparation process was relatively simple. The approximate experimental procedure was as follows, 100 m L three-necked flask was added 6.90 g (0.05 mol) of p-nitrotoluene, and 17.5 g (0.15 m o1) of chlorosulfone was slowly added with vigorous stirring, after finished, raise temperature up to 65 ℃, react for 24 hours. After completion of the reaction, the reaction solution was slowly poured into 100 m L of ice water. Extract with Dichloromethane, combined the organic layer, 50.0 m L of concentrated aqueous ammonia was added to the organic layer. Raise temperature to reflux for 2 hours, evaporated under reduced pressure. The filter cake was recrystallized by water, filtered and dried to obtain a yellow needle Crystalline 5-nitro-2-methylbenzenesulfonamide CAS number 6269-91-6, .

Thera. Category: Anti -cancer

Cas No.: 6269-91-6

Synonym: IFLAB-BB F1084-0158;BUTTPARK 52\04-61; BENZENESULFONAMIDE,2-METHYL-5-NITRO-;2-methyl-5-nitrobenzene-1-sulfonamide;2-Methyl-5-nitro-1-benzenesulfonamide

Molecular Formula: C7H8N2O4S

Molecular Weight: 216.21

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Pazopanib Intermediate lists:

2,3-Dimethyl-2H-indazol-6-amine, CAS  444731-72-0

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE,CAS 444731-73-1   

3-methyl-6-nitro-2H-indazole CAS number  1313372-75-6

2-Ethyl-5-nitrobenzenamine, CAS numbe  20191-74-6.

2-methyl-5-nitrobenzenesulfonamide  CAS number 6269-91-6,