5-Methyl-3,4-Diphenylisoxazole For Parecoxib Sodium CAS 37928-17-9

Basic Info

Model No.: 37928-17-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Parecoxib sodiuM inteMediate 5-Methyl-3,4-diphenylisoxazole cas number37928-17-9, there are two synthesis ideas, the first is use 1-phenyl acetone as raw material, and condensation with tetrahydropyrrole,and from a ring with benzyl cyanide N-oxide,remove tetrahydropyrrole in concentrated hydrochloric acid to form double keys to get 3,4-diphenyl-5-methylisoxazole, which is expensive and difficult to purchase. So it is not suitable for practical production. The second is use 1,2-diphenylethanone as raw material, with tetrahydropyrrole condensation, acetylation, followed cyclization under sodium acetate and hydroxylamine hydrochloride, then dehydration to 3,4 - diphenyl - 5 - methyl Isoxazole, the yield of this method is higher than the first yield, raw material procurement is relatively easy. So the feasibility of the second method is higher than the first method.

5-methyl-3,4-diphenylisoxazole 37928-17-9 is synthesis for PARECOXIB SODIUM, Molecular formula C16H13NO, Molecular weight 235.28052, the appearance of white crystalline powder, treatment for postoperative pain short-term treatment. At the same time it is the second generation of specific COX-2 inhibitors for the treatment of arthritis, osteoarthritis, gastrointestinal side effects. It is bigger amount produced intermediate of PARECOXIB SODIUM in our company. Inventory size is generally maintained at 100 kg or more. Our current customer base is mainly concentrated in the country, including drug registration and application companies and trading companies. Drug registration and applicaton company volume is generally small, the demand for trading companies has further expand trend. We are willing to work with the relevant demand party to make the product more bigger and stronger.

Thera. Category: Postoperative pain short-term treatment

Cas No.: 37928-17-9

Synonym:Parecoxib InterMediate (5-Mehyl-3,4-Diphenylisoxazole);5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate);Isoxazole, 5-Methyl-3,4-diphenyl- (Parecoxib sodiuM inteMediate);Isoxazole, 5-Methyl-3,4-diphenyl-;3,4-Diphenyl-5-methylisoxazole;5-Methyl-3,4-diphenylisoxazole;3-Phenyl-4-(4-aMinosulfonylbenzyl)-5-Methylisoxazole,Valdecoxib IMpurity A;Parecoxib SodiuM interMediate A;

Molecular Formula:C16H13NO

Molecular Weight: 235.28052                  

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Synthesis Pharmaceutical Intermediates

Related intermediate:

1) 5-Methyl-3,4-diphenylisoxazole cas number 37928-17-9

2) 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl chloride  CAS number 509074-26-4

3) Valecoxib cas number 81695-72-7,