4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl Chloride CAS Number 509074-26-4

Basic Info

Model No.: 509074-26-4

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl chloride is used for making Parecoxib sodium CAS number 509074-26-4. It is a high-level intermediate of parecoxib sodium, the main synthetic routes are below: 1. Use 1,2-diphenylethanone as raw material, with tetrahydropyrrole condensation, acetylation, followed cyclization and dehydration by sodium acetate and hydroxylamine hydrochloride to obtain 3,4-diphenyl-5-methyl isoxazole, and finally chlorosulfonation, ammonia and propionylation to get the target product, the total yield of this synthesis does not exceed 30%, the used dehydration mediums are trifluoroacetic acid, isopropyl alcohol, ethyl acetate, these substances acid are very strong, demanding high specification equipment, and the fluoride material has pollution to environment . 2. With 1,2-diphenylethylene as raw material, and form oxime with hydroxylamine hydrochloride, in the role of n-butyl lithium ethyl acetate condense the ring, and under the condition of trifluoroacetic acid and chlorosulfonic acid to obtain sulfonamide intermediates, And then acylate with propionic anhydride to get the target product, this method with n-butyl lithium reaction is absolutely required anhydrous and oxygen-free conditions below -10 ℃, it is not conducive to industrial production. 3. With 1,2-diphenylethylene as raw material, react with chlorosulfonic acid to get the first step product, the product under the action of pyridine and condense with acetyl chloride to obtain the second step product, the product take cyclization reaction with hydroxylamine hydrochloride to get the third step product, and then chlorinated, ammonia solution to get the fourth step product, and finally react with propionic anhydride to get the final target product. Comparison of the above three methods of preparation of 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl chloride CAS number 509074-26-4 , the third total yield is best, the most simple operation, the most moderate reaction conditions, so the third method is most suitable for industrial production

Thera. Category: Postoperative pain short-term treatment

Cas No.:  509074-26-4

Synonym:Parecoxib SodiuM IMpurity F;Valdecoxib Sulfonyl Chloride,Valdecoxib IMpurity F;4-(5-Methyl-3-phenylisoxazol-4-yl)benzene-1-sulfonyl chloride;4-(5-Methyl-3-phenyl-4-isoxazolyl)-benzenesulfonyl;Benzenesulfonyl chloride, 4-(5-methyl-3-phenyl-4-isoxazolyl)-;4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl Chloride;Valdecoxib IMpurity F;Valdecoxib Sulfonyl Chloride;

Molecular Formula:C16H12ClNO3S

Molecular Weight: 333.78938         

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Synthesis Pharmaceutical Intermediates

Related intermediate:

1) 5-Methyl-3,4-diphenylisoxazole cas number 37928-17-9

2) 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonyl chloride  CAS number 509074-26-4

3) Valecoxib cas number 81695-72-7,