2-Ethyl-5-Nitrobenzenamine(Pazopanib Intermediate) CAS Number 20191-74-6

Basic Info

Model No.: 20191-74-6

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale

Brand: VOLSENCHEM

Place of Origin: CHINA

Product Description

Pazopanib intermediate has the chemical name of  2-Ethyl-5-nitrobenzenamine, CAS number is 20191-74-6. It is the first step outcome material in the pazopanib reaction system. If only see the preparation of this intermediate alone, the synthetic method is very simple, but if it is aimed at the whole of pazopanib, It is necessary to carefully select the reaction route. There is a more reasonable method, the approximate experimental verification process is as follows, put 500 ml concentrated sulfuric acid into the 1L three-necked flask, cooled to 0 ° C, in part by adding o-ethyl aniline, then stirring ,after adding potassium nitrate,increase the temperature to room temperature reaction, After completion of the reaction, the reaction solution was slowly poured into 2.5 L of ice water and adjusted to pH 8 with 2 mol / L sodium hydroxide solution to precipitate a solid. The filter cake was washed successively with water, petroleum ether and dried in vacuo to give 141.1 g of the desired product,  2-Ethyl-5-nitrobenzenamine CAS 20191-74-6 with a reddish brown solid. The final yield in this way is about 85%, much higher than the reported in the literature of 70-75%. .

Thera. Category: Anti -cancer

Cas No.: 20191-74-6

Synonym:2-Ethyl-5-nitroaniline 2-Ethyl-5-nitrobenzenamine;2-Ethyl-5-nitrobenzenamine 98%;2-Ethyl-5-nitrobenzenamine ,98%;2-ethyl-5-nitroaniline;BenzenaMine, 2-ethyl-5-nitro-;2-Ethyl-5-nitro-phenylaMine;4-Nitro-2-amino-1-ethylbenzene;

Molecular Formula: C8H10N2O2

Molecular Weight: 166.179

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Pazopanib Intermediate lists:

2,3-Dimethyl-2H-indazol-6-amine, CAS  444731-72-0

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE,CAS 444731-73-1   

3-methyl-6-nitro-2H-indazole CAS number  1313372-75-6

2-Ethyl-5-nitrobenzenamine, CAS numbe  20191-74-6.

2-methyl-5-nitrobenzenesulfonamide  CAS number 6269-91-6,